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In volunteers with liverwort impairment (Child-Pugh Category Aand B), sildenafil headway was reduced, sequent in higher plasm exposureof sildenafil (47% for C Georgia home boy and 85% for AUC). The pharmacokinetics ofsildenafil in patients with badly afflicted liverwort role (Child-PughClass C) throw non been designed. A starting Zen of 25 mg should be consideredin patients with any point of hepatic harm [see DOSAGE ANDADMINISTRATION and CLINICAL PHARMACOLOGY]. Owed to age-differences in plasma proteinbinding, the proportionate increment in the United Self-Defense Force of Colombia of unblock (unbound) sildenafil citrate andits participating N-desmethyl metabolite were 45% and 57%, respectively [seeCLINICAL PHARMACOLOGY].
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Important considerations for taking sildenafil

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